Technical Report VII
Uncertainty of Measurement and Diagnostic Accuracy Measures.
A T Hatjimihail
Abstract
This Demonstration compares various diagnostic accuracy measures of two diagnostic tests. The two tests measure the same measurand, in normally distributed nondiseased and diseased populations, for various values of the prevalence of the disease, of the population means and standard deviations, and of the tests’ measurement uncertainty. A normal distribution of the uncertainty is assumed. The mean and the standard deviation of each population and the uncertainty of each test are measured in arbitrary units. The measures compared are the positive predictive value (PPV), the negative predictive value (NPV), the (diagnostic) odds ratio (OR), the likelihood ratio for a positive test result (LR+), and the likelihood ratio for a negative test result (LR−). The measures are calculated versus the sensitivity (Se) or the specificity (Sp) of each test. This can be selected by clicking the respective button. The available plot types are: both measures, partial derivatives of both measures with respect to measurement uncertainty, difference, and ratio of the two measures.
First Published
2009-05-26
Revised
2026-06-05
DOI
Citation
Hatjimihail AT. Uncertainty of Measurement and Diagnostic Accuracy Measures. Technical Report VII. Hellenic Complex Systems Laboratory; 2009. https://doi.org/10.5281/zenodo.20484072.
Source Notebook (Revised on 2026-06-05)
Terms of Use
The material made freely available by Hellenic Complex Systems Laboratory is subject to its Terms of Use.